If your Merak Mail Server is running behind a proxy server, there could be a problem receiving your Integrated Antivirus Updates. This is because the Avast engine used by Merak tries to connect directly to its Internet Antivirus Database.
You may need to set the Antivirus to use your proxy manually. Go to the Miscellaneous tab in the AntiVirus node and click the Setup button

This will open the AntiVirus settings file which you need to modify.
The portion of the file you are interested in is:
[Common]
NetAcc=-1
NetIP=
NetPort=0
NetUser=
NetPwd=
You should modify these settings according to your Proxy settings and the descriptions below.
Line | Description |
NetAcc | A type of access. A value is a number (-1) - (3) -1 ... use default settings 0 ... do not use proxy server 1 ... use IE settings for proxy server 2 ... HTTP proxy 3 ... SOCKS proxy |
NetIP | An IP address of proxy server |
NetPort | A port number where proxy server is running |
NetUser | Logon username for proxy server (in case a proxy server requires authentication) |
NetPwd | Logon password for proxy server (in case a proxy server requires authentication) |